About Us


  • We strive to eradicate difficult-to-treat and incurable diseases
  • We aspire to continuously innovate and develop technologies for efficiently improving the efficacy and safety of novel drugs

Mission and Objectives

  • To improve the quality of life in patients afflicted with incurable diseases with next-generation cell & gene therapy
  • To engineer mini-Organs with different genetic backgrounds (e.g., polymorphisms, missense/deletion/insertion mutations) for designing new therapeutics tailored for genetic diversity in the patient population
  • To capitalize on our proprietary and ever-advancing mini-Life Platform, our subsidiary, Novoheart, engineers a range of biomimetic human mini-Organs for effectively screening and accurately developing novel next-generation therapeutics for various incurable diseases at significantly reduced time and cost, thereby, maximizing the benefits while minimizing the side effects for patients
  • To build upon our bioengineered human tissue-based assays for disease modelling and drug discovery, our subsidiary, Sardocor, aspires to create the shortest regulatory path to the clinic for advancing effective next-generation cell & gene therapy
  • To complement our cell & gene therapy, we also have small molecule programs for treating a variety of diseases at different stages

Key Milestones


gene therapy proof-of-concept study performed in a rat model of heart failure by Dr. Roger Hajjar at Harvard University


translational gene therapy study performed in failing human heart cells isolated in cardiac transplant by Dr. Roger Hajjar


Dual gene therapy modulates excitability and contractility in guinea pig by Dr. Ronald Li and his colleagues


Intracoronary delivery in the pre-clinical pig model of heart failure by Dr. Roger Hajjar

genetically engineered human heart muscle cells derived from human embryonic stem cell by Dr. Ronald Li’s team

American Heart Association’s Best Basic Study of the Year


Gene-Based Biological Pacemaker by Dr. Ronald Li’s team

American Heart Association’s Ground-breaking Study of the Year


-in-man gene therapy trial for heart failure in the U.S. by Dr. Roger Hajjar

American Heart Association’s Best Basic Study of the Year

Patented technology for driving maturation of human heart cells by Dr. Ronald Li’s team


lab grown rat “heart-in-a-jar” by Dr. Kevin Costa


Invention of Alignment technology – groundwork for the human ventricular Cardiac Anisotropic Sheet (hvCAS) by Drs. Ronald Li and Michelle Khine


Rat engineered cardiac tissue – Precursor to human ventricular Cardiac Tissue Strip (hvCTS) by Dr. Kevin Costa


human “heart-in-a-jar” prototype created and tested by Dr. Ronald Li and Dr. Kevin Costa


Medera’s subsidiary, Novoheart, was established in 2014 to focus on Disease Modelling and Drug Discovery

hvCTS published by Drs. Ronald Li and Kevin Costa

Pfizer and Novoheart undertook a double-blinded drug screening study using the mini-Heart technology


human “heart-in-a-jar” created in Li and Costa lab


IND approval for novel gene therapy to inhibit phosphatase activity in heart failure

demonstration of gene editing to correct inherited cardiomyopathy in an engineered cardiac tissue strip model by Drs. Kevin Costa and Roger Hajjar


human mini-Heart models of Friedreich’s Ataxia was created by the collaboration of Novoheart and Pfizer


Novoheart was dual listed on Toronto and Frankfurt Stock Exchanges


Landmark Study Demonstrating the Use of Machine Learning to Accelerate Drug Screening


Patent on Pioneering New Multi-organoid Bioreactor Platform


Novoheart was awarded Top 50 Innovative Biotechnology Enterprises in the Greater Bay Area by KPMG China


Development of a high-throughput cardiac contractility screening system with Amgen


Drs. Roger Hajjar and Ronald Li co-founded Sardocor to develop next-generation gene therapies for heart failure and other difficult-to-treat diseases


Exclusive Agreement with Harvard University to Develop Next-Generation Human Heart-in-a-Jar


Partnership with AstraZeneca to co-develop a human mini-Heart model of Heart Failure with preserved Ejection Fraction (HFpEF)


Novoheart Named 2020 Venture 50 Company Ranked Among Year’s Top Performing Stocks in Life Sciences


1000 doses of Sardocor’s gene therapy drug SRD001/2 are available for patient injection


Novoheart was privatized, moved to the U.S. and restructured for merging with Sardocor to create a one-stop platform for disease modelling and drug discovery all the way to clinical trials


Sardocor was granted an open IND from the FDA to start gene therapy clinical trials for Heart Failure with preserved Ejection Fraction (HFpEF) and reduced Ejection Fraction (HFrEF)


Sardocor’s HFpEF, HFrEF and Duchenne Muscular Dystrophy (DMD) are anticipated to enter Phase 2B

Our Team

Senior Management

Dr. Ronald Li, PhD
Chairman, Chief Executive Officer & Founder

Dr. Roger Hajjar, MD
President & Scientific Co-Founder

Dr. Kevin Costa, PhD
Chief Scientific Officer & Scientific Co-Founder

Dr. Jonathan Plehn, MD
Chief Medical Officer

Mr. Jeffrey Rudy
Chief Operating Officer

Mr. Kenneth KC Wong

Dr. Wendy Keung, PhD
Vice-President, Scientific Operations

Dr. Erin Roberts, PhD
Deputy Chief Scientific Officer (Bioengineering)

Dr. Andy Wong, PhD
Head of Disease Modelling

Senior Advisor to Chairman and CEO


Scientific Advisory Board

Medera takes a multi-disciplinary approach to broadly focus on the discovery and development of next-generation therapeutics for some of the most challenging incurable diseases. Our SAB members with diverse world-class expertise lead different sub-groups, consisting of internal and external members who are experts in their specialties, and make scientific recommendations to Medera’s Management and Board of Directors.

Disease Modelling & Drug Discovery Subgroup

Dr. Mark Mercola, PhD

  • Professor of Medicine, Cardiovascular Research Institute, Stanford University. Former faculty at Harvard Medical School and University of California, San Diego
  • Recipient of NIH MERIT award for his work on heart formation
  • Dr. Mercola is known for identifying numerous pathways that are responsible for inducing and forming the heart, including the discovery that Wnt inhibition is a critical step in cardiogenesis that provided the conceptual basis and reagents for the large-scale production of cardiovascular tissues from pluripotent stem cells
  • Dr. Mercola’s academic research is focused on developing and using quantitative high throughput assays of patient-specific cardiomyocyte function to discover drug targets for preserving contractile function in heart failure and promoting regeneration following ischemic injury


Heart Failure with preserved Ejection Fraction (HFpEF) Subgroup

Dr. Michael Zile, MD

  • Professor of Medicine at the Medical University of South Carolina
  • Director of Cardiology in Ralph H. Johnson VA Medical Centre of Veteran’s affairs Medical Center in Charleston
  • Adjunct professor of bioengineering at Clemson University
  • Dr. Zile is a recognised leader in the area of cardiac function, CHF, diastolic heart failure and valvular heart disease
  • Dr. Zile’s research is supported by grants from National Heart, Lung and Blood Institute, the AHA, the Department of Veteran Affairs and MUSC

Heart Failure with reduced Ejection Fraction (HFrEF) Subgroup

Dr. Jean-Sébastien Hulot, MD

  • Professor of Medicine, Pharmacology at Paris University, Paris, France
  • Team Leader, Heart Failure Translation Research Lab, Paris Cardiovascular Research Center
  • Associate Professor of Medicine, Cardiology at the Cardiovascular Research Center at Mount Sinai School of Medicine in New York, USA from 2010-2014
  • Dr. Hulot leads an INSERM-labelled research team investigating on novel molecular mechanisms that drive heart failure
  • Dr. Hulot’s research focus is elucidation of mechanisms that drive pathological cardiac remodelling, including adverse fibrotic remodelling

Duchenne Muscular Dystrophy (DMD) Subgroup

Dr. Dongsheng Duan, PhD

  • Margaret Proctor Mulligan Professor in Medical Research Professor
  • Curators Distinguished Professor, School of Medicine, University of Missouri
  • Dr. Duan’s major research interest in understanding and treating Duchenne Muscular Dystrophy, with focus on the molecular and cellular biology of the disease gene, the disease mechanism and possible genetic therapies for the disease
  • Dr. Duan was part of a team that identified a key genetic sequence which is instrumental in DMD, which led to the successful treatment of dogs with the disease
  • Dr. Duan has received numerous recognitions including the American Society of Gene Therapy’s Outstanding New Investigator award